Introduction on juvenile macular degeneration

For a large number of aging people, they are suffering from juvenile macular degeneration. And a lot of young people also want to know more about juvenile macular degeneration in order to take precaution to this eye disease. However, they don't have a clear idea or find little information to learn about this. The following will give some introduction on juvenile macular degeneration and the recent researches on this eye disease.

First let us talk about the macula. Macula is a very important part of our eyes. It is in the center of the retina at the back of the eyes. What functions do they have? Actually our detailed and straight ahead vision is both decided by macula. So you can imagine if there is some problem with our macula, what kind of situation it will be. Researches show there are several forms of juvenile macular degeneration that can affect the macula, which finally lead to genetic mutation.

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Among all forms of juvenile macular degeneration, vitelliform macular degeneration is the best as it can be regarded as macular dystrophy. Vitelliform macular degeneration is a hereditary eye disease and can be transferred by genes. People can be diagnosed of vitelliform macular degeneration at their childhood or adolescence. Though it is minor disease, there are also several stages for it. There is a layer under the macula, caused retinal pigment epithelium (RPE). The first stage is there is a yellow cyst under the RPE, but this can not influence our vision for many years. And the second stage is when the cyst ruptures, and then the RAPE will be flooded by fluid and yellow deposits. The third stage is more serious. Patients will lose their central vision as the fluid and deposits will cause RPE degeneration. However, the peripheral vision still exists.


The most common form of macular degeneration is Stargardt's disease which was first discovered in 1901 by Karl Stargardt, who is a German ophthalmologist. After that, he did a lot of researches on this disease. And researches show the responsible gene, ABCR may be useful for future gene therapy. But as the clinical trials for different forms of juvenile macular degeneration are few, scientists still do not have enough information and can not prove the better way to treat it. And now there is a assumption that DHA dietary supplement may have some effect in improving macular functions with the ELOVL4 mutation. But scientists still need to do a lot of researches on patients with Stargardt-like macular dystrophy or Stargardt macular dystrophy to prove this assumption.

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